Sequential Ugi Four‐Component Reaction (4‐CR)/CH Activation Using (Diacetoxyiodo)benzene for the Synthesis of 3‐(Diphenylmethylidene)‐2,3‐dihydro‐1H‐indol‐2‐ones

A sequential Ugi four‐component reaction (4‐CR)/C? H activation using (diacetoxyiodo)benzene is reported. This process is a five‐component reaction of aromatic aldehydes, aniline derivatives, isocyanides, phenylpropiolic acid (3‐phenylprop‐2‐ynoic acid), and (diacetoxyiodo)benzene for the synthesis of 3‐(diphenylmethylidene)‐2,3‐dihydro‐1H‐indol‐2‐ones. This procedure offers several advantages such as good yields, high bond‐forming efficiency, selectivity, and short reaction times.     

Combining [Arene–Ru] with Azocarboxamide to Generate a Complex with Cytotoxic Properties

Azocarboxamide (azcH) has been combined for the first time with [Ru–Cym] to generate metal complexes with N,N‐ and N,O‐coordination mode, [(Cym)Ru(azc)Cl] and [(Cym)Ru(azcH)Cl]⁺[PF₆]^?. Geometric and electronic structures of the complexes are reported along with their in vitro activities against different tumour cell lines and preliminary results on solution chemistry. Compound [(Cym)Ru(azc)Cl] exhibited remarkable cytotoxic properties. It was cell‐type specific and had comparable IC₅₀ values towards both cancer cells and their drug‐resistant subline. A tenfold increase in the sensitivity towards [(Cym)Ru(azc)Cl] was noted for the tumour cells with depleted intracellular glutathione (GSH) level, suggesting the essential role of GSH in cell response to this compound.     

3,3'-(苯亚甲基)双吲哚的制备―一个推荐的有机化学合成实验

本文介绍了3,3’-(苯亚甲基)双吲哚的制备和柱层析分离实验的原理和操作步骤。该实验具有以下特点:(1)反应时间短,30min左右便可完成;(2)产物为粉红色,在进行硅胶板层析和层析柱时比较直观,适合于学生的实验教学;(3)反应物、催化剂和产物的极性相差很大,容易进行柱层析分离产物。该实验特别适合于综合性大学和地方高等师范院校化学和相关本科专业的"有机化学实验"或"综合化学实验"进行开设。     

基于 KHIMERA 的Se和Sn氧化动力学参数计算

反应速率常数和指前因子、活化能等动力学参数的准确性是研究痕量元素动力学模型的关键,在Se和Sn氧化过程的反应机理研究基础上,借助于量化软件Gaussview和Gaussian及动力学软件Khimera,采用量子化学从头计算理论对Se和Sn氧化过程进行研究,最终得到了在200~2000K温度区间内的反应速率k随温度T变化的关系,进一步计算了Arrhenius参数,得出了活化能随温度变化的关系,弥补了以往只能计算单个温度点的化学反应速率值的不足,为深入研究煤燃烧过程中Se和Sn的生成与排放的动力学模型提供了依据。     

骨中铊的微波消解ICP/AES标准加入测定法

建立骨骼的微波消解和金属毒物铊的ICP/AES标准加入分析方法。取0.2g骨粉于聚四氟乙烯消解管中,加入3.0mL浓硝酸及0.5mL双氧水,进行微波消解。结束后,用2%硝酸定容至10.0mL。根据标准加入法进行ICP-AES定量分析。方法的回收率为99.4%,检出限为5.1ng/g,线性范围为5~500 ng/mL。该方法操作简便,回收率高,检出限低,线性范围宽,可多元素同时测定,结果可靠。     

(英)硫酸氢钾高效催化一锅法合成5-未取代的3,4-二氢嘧啶-2(1H)-酮

无溶剂条件下,硫酸氢钾可有效催化芳香醛、苯乙酮衍生物和脲的三组分"一锅法"Biginelli反应来合成5-未取代的3,4-二氢嘧啶-2(1H)-酮。确定了优化反应条件。产品结构经IR、1H NMR、MS和元素分析进行表征。     

厌氧-曝气生物滤池处理水杨酸废水的研究

采用厌氧-曝气生物滤池(AF-BAF)工艺处理工业水杨酸废水,研究了不同进水ρ[COD(NaAc)]/ρ[COD(SA)]比值[表示乙酸钠与水杨酸(SA)的化学需氧量(COD)浓度配比]对有机物去除和脱氮效果的影响。结果表明,当进水SA浓度低于187mg/L时,经AF工艺处理后,废水生化需氧量(BOD)5/COD由0.27增大至0.38,UV254/氧化还原电位(ORP)由-7.68增大至-3.22,可生化性明显提高。最佳水力停留时间(HRT)为10h,当比值为300∶300时,COD去除率最高(91.74%),SA去除率为91.4%;当比值为0∶600时,COD去除率最低(42%),SA去除率为52.48%。进水碳源变化对NH4+-N去除影响较小,去除率可达99.83%。SA功能菌依赖于非SA功能菌分泌的代谢产物生存,失去非SA功能菌分泌的代谢产物后,SA功能菌的活性开始降低。     

6-氯-N,N-二甲基嘧啶-4-胺的晶体结构研究

X-射线单晶衍射结果表明,所合成的6-氯-N,N-二甲基嘧啶-4-胺的晶体结构属正交晶系,Pbca空间群,晶胞参数为a=10.922(2),b=7.386(3),c=17.861(6)。由于在其晶格内存在着潜在的C—H…N和C—H…Cl两类分子间弱相互作用力,形成了二维网络结构,化合物变得更加稳定。     

以“偏光显微镜观察高聚物的球晶”为例的高分子物理实验项目改革

本文对高分子物理实验教学改革进行了思考,提出实验项目的建设应当成为实验教学改革的核心,而实验项目的改革不应当局限在将最新的科研成果引入到实验教学中。以"偏光显微镜观察聚合物的球晶"这一传统实验为例,更为有效的办法可以是通过系统化的设计扩展实验项目内容,注重实验项目实施过程中多知识点的串联以及实验结果获取过程的思维过程培养,从而将传统的验证性实验项目转化为综合性实验项目,有力提升实验教学的效果。     

Structure-based study of antiamyloidogenic cyclic d,l-α-peptides

Protein misfolding and aggregation are the hallmarks of many devastating diseases. We have previously shown that cyclic d,l-α-peptide CP-2 reacts and stabilizes less toxic forms of amyloid β (Aβ), and protects the cells from Aβ-induced toxicity. Here, we performed extensive structure-based studies on CP-2 to elucidate the contribution of each residue to the total antiamyloidogenic activity and determine the interactions that are involved between CP-2 and Aβ. We showed that the hydrophobicity of CP-2 analogs correlates with their antiamyloidogenic potency, however, aromatic interactions are even more important for this activity. The antiamyloidogenic activity of CP-2 analogs also correlates with their ability to self-assemble, as shown by the critical micelle concentration measurements. The cell survival studies performed on rat pheochromocytoma PC-12 cells suggest that incorporation of an additional aromatic residue to the CP-2's sequence increases its protective effect against Aβ42-induced toxicity.